Understanding ligand-receptor non-covalent binding kinetics using molecular modeling
نویسندگان
چکیده
منابع مشابه
Understanding ligand-receptor non-covalent binding kinetics using molecular modeling.
Kinetic properties may serve as critical differentiators and predictors of drug efficacy and safety, in addition to the traditionally focused binding affinity. However the quantitative structure-kinetics relationship (QSKR) for modeling and ligand design is still poorly understood. This review provides an introduction to the kinetics of drug binding from a fundamental chemistry perspective. We ...
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ژورنال
عنوان ژورنال: Frontiers in Bioscience
سال: 2017
ISSN: 1093-9946,1093-4715
DOI: 10.2741/4527